![]() ![]() Research shows that the pathogenesis of intervertebral disc degeneration may be associated with a decrease of the diffusion rate. One case of grade V degeneration improved to grade III, while another case of grade V improved to grade VI. There were four cases of grade IV degeneration that improved to grade II in two patients and grade III in two patients. Additionally, five cases of grade III degeneration improved to grade I. In the ISOBAR TTL group after 24 months, two cases of grade II and 1 case of grade III degenerative intervertebral discs improved to grade I. MRI imaging evaluation Using the Pfirrmann grade standard of intervertebral disc degeneration, the preoperative and postoperative findings were compared. ![]() The following grading was used: (1) I–II grade: an ellipse ROI in center part of the disc was drawn, containing the nucleus, about the size of 60–80 mm 2, (2) III–V grade: because the boundary of nucleus pulposus in fiber ring was not clear, irregular or oval ROI could be drawn, according to the position of the nucleus pulposus, (3) every ROI measurement was repeated three times, taking the mean value and recording every disc ROI and apparent diffusion coefficient (ADC).
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